Extracellular vesicles (EVs) are nowadays known to be mediators of cell-to-cell communication involved in physiological and pathological processes. The current expectation is their use as specific biomarkers and therapeutic tools due to their inner characteristics. However, several investigations still need to be done before we can use them in the clinic. First, their categorization is still under debate, although an accurate classification of EVs subtypes should be based on physical characteristics, biochemical composition or condition description of the cell of origin. Second, EVs carry lipids, proteins and nucleic acids that can induce epigenetic modifications on target cells. These cargos, as well as EVs biogenesis, shedding and uptake is both ageing and redox sensitive. More specifically, senescence and oxidative stress increase EVs release, and their altered content can trigger antioxidant but also prooxidant responses in target cells thereby modulating the redox status. Further analysis would help to asses EVs role in the development and progression of oxidative stress-related pathologies.
Published by Dr AL Lukas
Medico en Cirugia General, Cirugia Plastica y Traumatologia . Veterano de 3 guerras.. AL Lukas no es mi nombre real, pues como Cubano-Americano las condiciones que me obligaron a salir de mi pais aun persisten ,desgraciadamente, y me veo obligado a usar este Nickname. Anyway lo importante es el mensaje, no el mensajero. Pretendo solo contar y compartir mi experiencia y manera de pensar como medico y no trazar pautas. Consulte siempre con su medico antes de tomar cualquier decision sobre su salud. View all posts by Dr AL Lukas